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Enzymatic Interconversion of Isomorphic Fluorescent Nucleosides: Adenosine Deaminase Transforms (th)A to (th)I, Two Distinct Fluorophores

Adenosine deaminase, a major enzyme involved in purine metabolism, converts an isomorphic fluorescent analogue of adenosine ((th)A) to an isomorphic inosine analogue ((th)I), which possesses distinct spectral features, allowing one to monitor the enzyme-catalyzed reaction and its inhibition in real...

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Bibliographic Details
Main Authors: Sinkeldam, Renatus W., McCoy, Lisa S., Shin, Dongwon, Tor, Yitzhak
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947497/
https://ncbi.nlm.nih.gov/pubmed/24288262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201307064
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