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Construction of a novel expression cassette for increasing transgene expression in vivo in endothelial cells of large blood vessels

The success of gene therapy hinges on achievement of adequate transgene expression. To ensure high transgene expression, many gene-therapy vectors include highly active virus-derived transcriptional elements. Other vectors include tissue-specific eukaryotic transcriptional elements, intended to limi...

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Detalhes bibliográficos
Main Authors: Dronadula, Nagadhara, Du, Liang, Flynn, Rowan, Buckler, Joshua, Kho, Jordan, Jiang, Zhilong, Tanaka, Shinji, Dichek, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093449/
https://ncbi.nlm.nih.gov/pubmed/21179172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2010.173
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