Structures of human exonuclease I DNA complexes suggest a unified mechanism for nuclease family

Human exonuclease 1 (hExo1) plays important roles in DNA repair and recombination processes that maintain genomic integrity. It is a member of the 5′ structure-specific nuclease family of exonucleases and endonucleases that includes FEN-1, XPG, and GEN1. We present structures of hExo1 in complex wit...

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Hauptverfasser: Orans, Jillian, McSweeney, Elizabeth A., Iyer, Ravi R., Hast, Michael A., Hellinga, Homme W., Modrich, Paul, Beese, Lorena S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093132/
https://ncbi.nlm.nih.gov/pubmed/21496642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.005
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