Nonsteroidal Anti-inflammatory Drugs Inhibit Vascular Smooth Muscle Cell Proliferation by Enabling the Ca(2+)-dependent Inactivation of Calcium Release-activated Calcium/Orai Channels Normally Prevented by Mitochondria

Abnormal vascular smooth muscle cell (VSMC) proliferation contributes to occlusive and proliferative disorders of the vessel wall. Salicylate and other nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit VSMC proliferation by an unknown mechanism unrelated to anti-inflammatory activity. In search...

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Bibliographic Details
Main Authors: Muñoz, Eva, Valero, Ruth A., Quintana, Ariel, Hoth, Markus, Núñez, Lucía, Villalobos, Carlos
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091227/
https://ncbi.nlm.nih.gov/pubmed/21402693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198952
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