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The Orai1 Severe Combined Immune Deficiency Mutation and Calcium Release-activated Ca(2+) Channel Function in the Heterozygous Condition
Homozygous expression of Orai1 bearing the R91W mutation results in the complete abrogation of currents through the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels, resulting in a form of hereditary severe combined immune deficiency (SCID) syndrome (Feske, S., Gwack, Y., Prakriya, M.,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652263/ https://ncbi.nlm.nih.gov/pubmed/19075015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808346200 |
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