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Proteasomal dysfunction in aging and Huntington disease
Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cells to avoid toxicity. Eukaryotic cells have two main routes for clearing misfolded or toxic proteins: the ubiquitin-proteasome and autophagy-lysosome pathways. The ubiquitin-pr...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090713/ https://ncbi.nlm.nih.gov/pubmed/21145396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.11.018 |
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