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Multiple pathways contribute to the pathogenesis of Huntington disease

Huntington disease (HD) is caused by expansion of a polyglutamine (polyQ) domain in the protein known as huntingtin (htt), and the disease is characterized by selective neurodegeneration. Expansion of the polyQ domain is not exclusive to HD, but occurs in eight other inherited neurodegenerative diso...

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Bibliographic Details
Main Authors: Li, Shihua, Li, Xiao-Jiang
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1764744/
https://ncbi.nlm.nih.gov/pubmed/17173700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-1-19
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