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Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy
Huntington’s disease (HD) is caused by a genetic mutation that results in polyglutamine expansion in the N-terminal regions of huntingtin. As a result, this polyQ expansion leads to the misfolding and aggregation of mutant huntingtin as well as age-dependent neurodegeneration. The genetic mutation i...
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| Veröffentlicht in: | Drug Des Devel Ther |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4404937/ https://ncbi.nlm.nih.gov/pubmed/25931812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S58470 |
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