Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...

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Detalhes bibliográficos
Main Authors: Kharas, Michael G, Lengner, Christopher J, Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W, Scholl, Claudia, Fröhling, Stefan, Fleming, Mark, Ebert, Benjamin L, Gilliland, D Gary, Jaenisch, Rudolf, Daley, George Q
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090658/
https://ncbi.nlm.nih.gov/pubmed/20616797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2187
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