Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...

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Bibliografiset tiedot
Päätekijät: Kharas, Michael G, Lengner, Christopher J, Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W, Scholl, Claudia, Fröhling, Stefan, Fleming, Mark, Ebert, Benjamin L, Gilliland, D Gary, Jaenisch, Rudolf, Daley, George Q
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090658/
https://ncbi.nlm.nih.gov/pubmed/20616797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2187
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