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The Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase (HDAC) Inhibitor

The efficient total synthesis of the recently described natural substance largazole (1) and it’s active metabolite largazole thiol (2) is described. The synthesis required eight linear steps and proceeded in 37% overall yield. It is demonstrated that largazole is a pro-drug, that is activated by rem...

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Bibliografiske detaljer
Main Authors: Bowers, Albert, West, Nathan, Taunton, Jack, Schreiber, Stuart L., Bradner, James E., Williams, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090445/
https://ncbi.nlm.nih.gov/pubmed/18642817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8033763
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