FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ

Nimustine (ACNU) and temozolomide (TMZ) are DNA alkylating agents which are commonly used in chemotherapy for glioblastomas. ACNU is a DNA cross-linking agent and TMZ is a methylating agent. The therapeutic efficacy of these agents is limited by the development of resistance. In this work, the role...

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Bibliografiske detaljer
Main Authors: Kondo, Natsuko, Takahashi, Akihisa, Mori, Eiichiro, Noda, Taichi, Zdzienicka, Małgorzata Z., Thompson, Larry H., Helleday, Thomas, Suzuki, Minoru, Kinashi, Yuko, Masunaga, Shinichiro, Ono, Koji, Hasegawa, Masatoshi, Ohnishi, Takeo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090409/
https://ncbi.nlm.nih.gov/pubmed/21573016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019659
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