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DNA ligase IV is a potential molecular target in Nimustine (ACNU) sensitivity
Nimustine [1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea; ACNU] is a chloroethylating agent which is used in chemotherapy for glioblastomas. It has been reported that ACNU induces several kinds of DNA lesions such as alkylating modification on base and double-strand breaks...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3032982/ https://ncbi.nlm.nih.gov/pubmed/20487264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2010.01591.x |
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