DNA ligase IV is a potential molecular target in Nimustine (ACNU) sensitivity

Nimustine [1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea; ACNU] is a chloroethylating agent which is used in chemotherapy for glioblastomas. It has been reported that ACNU induces several kinds of DNA lesions such as alkylating modification on base and double-strand breaks...

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Detalhes bibliográficos
Main Authors: Kondo, Natsuko, Takahashi, Akihisa, Mori, Eiichiro, Noda, Taichi, Su, Xiaoming, Ohnishi, Ken, McKinnon, Peter J., Sakaki, Toshisuke, Nakase, Hiroyuki, Ohnishi, Takeo
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032982/
https://ncbi.nlm.nih.gov/pubmed/20487264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2010.01591.x
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