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Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2
Hedonic reward, dependence and addiction are unwanted effects of opioid analgesics, linked to the phasic cycle of μ opioid receptor activation, tolerance and withdrawal. In vitro studies of recombinant G protein coupled receptors (GPCRs) over expressed in cell lines reveal an alternative tonic signa...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3090352/ https://ncbi.nlm.nih.gov/pubmed/21486473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-24 |
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