Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2

Hedonic reward, dependence and addiction are unwanted effects of opioid analgesics, linked to the phasic cycle of μ opioid receptor activation, tolerance and withdrawal. In vitro studies of recombinant G protein coupled receptors (GPCRs) over expressed in cell lines reveal an alternative tonic signa...

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Detalhes bibliográficos
Main Authors: Lam, Hoa, Maga, Matthew, Pradhan, Amynah, Evans, Christopher J, Maidment, Nigel T, Hales, Tim G, Walwyn, Wendy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090352/
https://ncbi.nlm.nih.gov/pubmed/21486473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-24
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