Ligand-Directed Trafficking of the δ-Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance

δ-Opioid receptors are G-protein-coupled receptors that regulate nociceptive and emotional responses. It has been well established that distinct agonists acting at the same G-protein-coupled receptor can engage different signaling or regulatory responses. This concept, known as biased agonism, has i...

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Bibliographic Details
Main Authors: Pradhan, Amynah A. A., Walwyn, Wendy, Nozaki, Chihiro, Filliol, Dominique, Erbs, Eric, Matifas, Audrey, Evans, Christopher, Kieffer, Brigitte L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086517/
https://ncbi.nlm.nih.gov/pubmed/21147985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3748-10.2010
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