Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1

Mature Xenopus oocytes are arrested in meiosis by the activity of XErp1/Emi2, an inhibitor of the ubiquitin-ligase anaphase-promoting complex/cyclosome (APC/C). On fertilization, XErp1 is degraded, resulting in APC/C activation and the consequent degradation of cell-cycle regulators and exit from me...

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Bibliographische Detailangaben
Hauptverfasser: Hörmanseder, Eva, Tischer, Thomas, Heubes, Simone, Stemmann, Olaf, Mayer, Thomas U
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Scientific Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090011/
https://ncbi.nlm.nih.gov/pubmed/21399619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.32
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