Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

The multisubunit ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for mitosis by promoting timely degradation of cyclin B1. APC/C is tightly regulated by the spindle assembly checkpoint (SAC), which involves MPS1 and MAD2-dependent temporal inhibition of APC/C. We analyzed...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wild, Thomas, Budzowska, Magda, Hellmuth, Susanne, Eibes, Susana, Karemore, Gopal, Barisic, Marin, Stemmann, Olaf, Choudhary, Chunaram
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289045/
https://ncbi.nlm.nih.gov/pubmed/30485802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.104
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