Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

The multisubunit ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for mitosis by promoting timely degradation of cyclin B1. APC/C is tightly regulated by the spindle assembly checkpoint (SAC), which involves MPS1 and MAD2-dependent temporal inhibition of APC/C. We analyzed...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Wild, Thomas, Budzowska, Magda, Hellmuth, Susanne, Eibes, Susana, Karemore, Gopal, Barisic, Marin, Stemmann, Olaf, Choudhary, Chunaram
Format: Artigo
Langue:Inglês
Publié: Cell Press 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289045/
https://ncbi.nlm.nih.gov/pubmed/30485802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.104
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires