Daily Treatment with SMTC1100, a Novel Small Molecule Utrophin Upregulator, Dramatically Reduces the Dystrophic Symptoms in the mdx Mouse

BACKGROUND: Duchenne muscular dystrophy (DMD) is a lethal, progressive muscle wasting disease caused by a loss of sarcolemmal bound dystrophin, which results in the death of the muscle fibers leading to the gradual depletion of skeletal muscle. There is significant evidence demonstrating that increa...

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Main Authors: Tinsley, Jonathon M., Fairclough, Rebecca J., Storer, Richard, Wilkes, Fraser J., Potter, Allyson C., Squire, Sarah E., Powell, Dave S., Cozzoli, Anna, Capogrosso, Roberta F., Lambert, Adam, Wilson, Francis X., Wren, Stephen P., De Luca, Annamaria, Davies, Kay E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089598/
https://ncbi.nlm.nih.gov/pubmed/21573153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019189
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