Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer disease (AD) and likely contributes to neuropathology through various pathways. Here we report that the intracellular trafficking of apoE4 is impaired in Neuro-2a cells and primary neurons, as shown by measuring fluorescence reco...

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Hauptverfasser: Brodbeck, Jens, McGuire, Jim, Liu, Zhaoping, Meyer-Franke, Anke, Balestra, Maureen E., Jeong, Dah-eun, Pleiss, Mike, McComas, Casey, Hess, Fred, Witter, David, Peterson, Scott, Childers, Matthew, Goulet, Mark, Liverton, Nigel, Hargreaves, Richard, Freedman, Stephen, Weisgraber, Karl H., Mahley, Robert W., Huang, Yadong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089564/
https://ncbi.nlm.nih.gov/pubmed/21454574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217380
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