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Small-molecule Structure Correctors Target Abnormal Protein Structure and Function: The Structure Corrector Rescue of Apolipoprotein E4–associated Neuropathology
An attractive strategy to treat proteinopathies—diseases caused by malformed or misfolded proteins—is to restore protein function by inducing proper three-dimensional structure. We hypothesized that this approach would be effective in reversing the detrimental effects of apolipoprotein (apo) E4, the...
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| Pubblicato in: | J Med Chem |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4904786/ https://ncbi.nlm.nih.gov/pubmed/23013167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008618 |
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