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Apolipoprotein E Sets the Stage: Response to Injury Triggers Neuropathology, Including Alzheimer's Disease
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease and is associated with poor clinical outcome following traumatic brain injury and other neuropathological disorders. Protein instability and an isoform-specific apoE property called domain interaction are responsib...
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| Publié dans: | Neuron |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891195/ https://ncbi.nlm.nih.gov/pubmed/23217737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.11.020 |
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