Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer disease (AD) and likely contributes to neuropathology through various pathways. Here we report that the intracellular trafficking of apoE4 is impaired in Neuro-2a cells and primary neurons, as shown by measuring fluorescence reco...

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Détails bibliographiques
Auteurs principaux: Brodbeck, Jens, McGuire, Jim, Liu, Zhaoping, Meyer-Franke, Anke, Balestra, Maureen E., Jeong, Dah-eun, Pleiss, Mike, McComas, Casey, Hess, Fred, Witter, David, Peterson, Scott, Childers, Matthew, Goulet, Mark, Liverton, Nigel, Hargreaves, Richard, Freedman, Stephen, Weisgraber, Karl H., Mahley, Robert W., Huang, Yadong
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089564/
https://ncbi.nlm.nih.gov/pubmed/21454574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217380
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