Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference

The CAG repeat expansions that occur in translated regions of specific genes can cause human genetic disorders known as polyglutamine (poly-Q)-triggered diseases. Huntington’s disease and spinobulbar muscular atrophy (SBMA) are examples of these diseases in which underlying mutations are localized n...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: de Mezer, Mateusz, Wojciechowska, Marzena, Napierala, Marek, Sobczak, Krzysztof, Krzyzosiak, Wlodzimierz J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2011
Gaiak:
RNA
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089464/
https://ncbi.nlm.nih.gov/pubmed/21247881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1323
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