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Context dependence of Checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumour suppressor
Inherited mutations in the tumour suppressor BRCA2 predispose to pancreatic adenocarcinomas, which carry activating mutations in the KRAS oncogene in >95% of cases, as well as frequent TP53 inactivation. Here, we have established an RNA interference (RNAi) screen to identify genes whose depletion...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087888/ https://ncbi.nlm.nih.gov/pubmed/21289082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0781 |
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