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In search of the tumour-suppressor functions of BRCA1 and BRCA2
Hereditary breast and ovarian cancer syndromes can be caused by loss-of-function germline mutations in one of two tumour-suppressor genes, BRCA1 and BRCA2 (ref. 1). Each gene product interacts with recombination/DNA repair proteins in pathways that participate in preserving intact chromosome structu...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2981135/ https://ncbi.nlm.nih.gov/pubmed/11100717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35044000 |
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