Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization

PURPOSE: Dendritic cells may be the most effective way of delivering oncolytic viruses to patients. Reovirus, a naturally occurring oncolytic virus, is currently undergoing early clinical trials; however, intravenous delivery of the virus is hampered by pre-existing anti-viral immunity. Systemic del...

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Hlavní autoři: Ilett, Elizabeth J., Bárcena, Montserrat, Errington-Mais, Fiona, Griffin, Stephen, Harrington, Kevin J., Pandha, Hardev S., Coffey, Matthew, Selby, Peter J., Limpens, Ronald W.A.L., Mommaas, Mieke, Hoeben, Rob C., Vile, Richard G., Melcher, Alan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087679/
https://ncbi.nlm.nih.gov/pubmed/21389099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3266
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