Lymphokine-activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites

Reovirus is an oncolytic virus (OV), which acts by both direct tumor cell killing and priming of antitumor immunity. A major obstacle for effective oncolytic virotherapy is effective delivery of OV to tumor cells. Ovarian cancer is often confined to the peritoneal cavity and therefore i.p. delivery...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Jennings, VA, Ilett, EJ, Scott, KJ, West, EJ, Vile, R, Pandha, H, Harrington, K, Young, A, Hall, GD, Coffey, M, Selby, P, Errington-Mais, F, Melcher, AA
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321045/
https://ncbi.nlm.nih.gov/pubmed/23982804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28450
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