Lymphokine-activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites

Reovirus is an oncolytic virus (OV), which acts by both direct tumor cell killing and priming of antitumor immunity. A major obstacle for effective oncolytic virotherapy is effective delivery of OV to tumor cells. Ovarian cancer is often confined to the peritoneal cavity and therefore i.p. delivery...

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Vydáno v:Int J Cancer
Hlavní autoři: Jennings, VA, Ilett, EJ, Scott, KJ, West, EJ, Vile, R, Pandha, H, Harrington, K, Young, A, Hall, GD, Coffey, M, Selby, P, Errington-Mais, F, Melcher, AA
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Tumor Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321045/
https://ncbi.nlm.nih.gov/pubmed/23982804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28450
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