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The structure of the PERK kinase domain suggests the mechanism for its activation

The endoplasmic reticulum (ER) unfolded protein response (UPR) is comprised of several intracellular signaling pathways that alleviate ER stress. The ER-localized transmembrane kinase PERK is one of three major ER stress transducers. Oligomerization of PERK’s N-terminal ER luminal domain by ER stres...

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Autors principals: Cui, Wenjun, Li, Jingzhi, Ron, David, Sha, Bingdong
Format: Artigo
Idioma:Inglês
Publicat: International Union of Crystallography 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087621/
https://ncbi.nlm.nih.gov/pubmed/21543844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911006445
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