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The structure of the PERK kinase domain suggests the mechanism for its activation

The endoplasmic reticulum (ER) unfolded protein response (UPR) is comprised of several intracellular signaling pathways that alleviate ER stress. The ER-localized transmembrane kinase PERK is one of three major ER stress transducers. Oligomerization of PERK’s N-terminal ER luminal domain by ER stres...

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Bibliografiske detaljer
Main Authors: Cui, Wenjun, Li, Jingzhi, Ron, David, Sha, Bingdong
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087621/
https://ncbi.nlm.nih.gov/pubmed/21543844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911006445
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