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The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins
PERK is one of the major sensor proteins which can detect the protein-folding imbalance generated by endoplasmic reticulum (ER) stress. It remains unclear how the sensor protein PERK is activated by ER stress. It has been demonstrated that the PERK luminal domain can recognize and selectively intera...
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| Publicado no: | Acta Crystallogr D Struct Biol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137225/ https://ncbi.nlm.nih.gov/pubmed/27917829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798316018064 |
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