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The structure of the PERK kinase domain suggests the mechanism for its activation
The endoplasmic reticulum (ER) unfolded protein response (UPR) is comprised of several intracellular signaling pathways that alleviate ER stress. The ER-localized transmembrane kinase PERK is one of three major ER stress transducers. Oligomerization of PERK’s N-terminal ER luminal domain by ER stres...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
International Union of Crystallography
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087621/ https://ncbi.nlm.nih.gov/pubmed/21543844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911006445 |
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