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The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity
Murine protein serine/threonine kinase 38 (MPK38) is the murine orthologue of human maternal embryonic leucine-zipper kinase (MELK), which belongs to the SNF1/AMPK family. MELK is considered to be a promising drug target for anticancer therapy because overexpression and hyperactivation of MELK is co...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3940201/ https://ncbi.nlm.nih.gov/pubmed/24531485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004713027806 |
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