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UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor
BiP is a major ER chaperone and suggested to act as primary sensor in the activation of the unfolded protein response (UPR). How BiP operates as a molecular chaperone and as an ER stress sensor is unknown. Here, by reconstituting components of human UPR, ER stress and BiP chaperone systems, we disco...
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| Publicado en: | Nat Struct Mol Biol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6858872/ https://ncbi.nlm.nih.gov/pubmed/31695187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0324-9 |
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