A mammalianized synthetic nitroreductase gene for high-level expression

BACKGROUND: The nitroreductase/5-(azaridin-1-yl)-2,4-dinitrobenzamide (NTR/CB1954) enzyme/prodrug system is considered as a promising candidate for anti-cancer strategies by gene-directed enzyme prodrug therapy (GDEPT) and has recently entered clinical trials. It requires the genetic modification of...

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Bibliographic Details
Main Authors: Grohmann, Maik, Paulmann, Nils, Fleischhauer, Sebastian, Vowinckel, Jakob, Priller, Josef, Walther, Diego J
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087338/
https://ncbi.nlm.nih.gov/pubmed/19712451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-301
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