Structure of an agonist-bound human A(2A) adenosine receptor

Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. Here we report the crystal structure of the A(2A) adenosine receptor (A(2A)AR) bound to an agonist UK-432097 at 2.7 angstrom resolution. Relative to in...

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Bibliografiska uppgifter
Huvudupphovsmän: Xu, Fei, Wu, Huixian, Katritch, Vsevolod, Han, Gye Won, Jacobson, Kenneth A., Gao, Zhan-Guo, Cherezov, Vadim, Stevens, Raymond C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086811/
https://ncbi.nlm.nih.gov/pubmed/21393508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1202793
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