Human Flap Endonuclease Structures, DNA Double Base Flipping and a Unified Understanding of the FEN1 Superfamily

Flap endonuclease (FEN1), essential for DNA replication and repair, removes RNA and DNA 5′-flaps. FEN1 5′ nuclease superfamily members acting in nucleotide excision repair (XPG), mismatch repair (EXO1) and homologous recombination (GEN1) paradoxically incise structurally distinct bubbles, ends or Ho...

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Autors principals: Tsutakawa, Susan E., Classen, Scott, Chapados, Brian R., Arvai, Andy, Finger, L. David, Guenther, Grant, Tomlinson, Christopher G, Thompson, Peter, Sarker, Altaf H., Shen, Binghui, Cooper, Priscilla K., Grasby, Jane A., Tainer, John A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086263/
https://ncbi.nlm.nih.gov/pubmed/21496641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.004
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