Cisplatin pharmacogenetics, DNA repair polymorphisms, and esophageal cancer outcomes

OBJECTIVES: Genetic variations or polymorphisms within genes of the nucleotide excision repair (NER) pathway alter DNA repair capacity. Reduced DNA repair (NER) capacity may result in tumors that are more susceptible to cisplatin chemotherapy, which functions by causing DNA damage. We investigated t...

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Hlavní autoři: Bradbury, Penelope A., Kulke, Matthew H., Heist, Rebecca S., Zhou, Wei, Ma, Clement, Xu, Wei, Marshall, Ariela L., Zhai, Rihong, Hooshmand, Susanne M., Asomaning, Kofi, Su, Li, Shepherd, Frances A., Lynch, Thomas J., Wain, John C., Christiani, David C., Liu, Geoffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085844/
https://ncbi.nlm.nih.gov/pubmed/19620936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32832f3010
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