Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma

The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We...

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Main Authors: Cheung, Winson Y., Zhai, Rihong, Bradbury, Penny, Hopkins, Jessica, Kulke, Matthew H., Heist, Rebecca S., Asomaning, Kofi, Ma, Clement, Xu, Wei, Wang, Zhaoxi, Hooshmand, Suzanne, Su, Li, Christiani, David C., Liu, Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3908453/
https://ncbi.nlm.nih.gov/pubmed/22422400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27541
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