mTORC1 and mTORC2 regulate EMT, motility and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways

Activation of phosphatidylinositol 3-kinase (PI3K)/Akt signaling is associated with growth and progression of colorectal cancer (CRC). We have previously shown that the mammalian target of rapamycin (mTOR) kinase, a downstream effector of PI3K/Akt signaling, regulates tumorigenesis of CRC. However,...

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Hauptverfasser: Gulhati, Pat, Bowen, Kanika A., Liu, Jianyu, Stevens, Payton D., Rychahou, Piotr G., Chen, Min, Lee, Eun Y., Weiss, Heidi L., O’Connor, Kathleen L., Gao, Tianyan, Evers, B. Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085654/
https://ncbi.nlm.nih.gov/pubmed/21430067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4058
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