TARGETED INHIBITION OF mTOR SIGNALING INHIBITS TUMORIGENESIS OF COLORECTAL CANCER

PURPOSE: The mammalian target of rapamycin (mTOR) kinase acts downstream of PI3K/Akt to regulate cellular growth, metabolism and cytoskeleton. Since approximately 60% of sporadic colorectal cancers (CRCs) exhibit high levels of activated Akt, we determined whether downstream mTOR signaling pathway c...

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Detaylı Bibliyografya
Asıl Yazarlar: Gulhati, Pat, Cai, Qingsong, Li, Jing, Liu, Jianyu, Rychahou, Piotr G., Qiu, Suimin, Lee, Eun Y., Silva, Scott R., Bowen, Kanika A., Gao, Tianyan, Evers, B. Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898570/
https://ncbi.nlm.nih.gov/pubmed/19934294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1249
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