Potent and Selective Small Molecule Inhibitors of Specific Isoforms of Cdc2-like Kinases (Clk) and Dual Specificity Tyrosine-Phosphorylation-Regulated Kinases (Dyrk)

Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan.

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Detalhes bibliográficos
Main Authors: Rosenthal, Andrew S., Tanega, Cordelle, Shen, Min, Mott, Bryan T., Bougie, James M., Nguyen, Dac-Trung, Misteli, Tom, Auld, Douglas S., Maloney, David J., Thomas, Craig J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085634/
https://ncbi.nlm.nih.gov/pubmed/21450467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.02.114
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