Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315

Substituted pyrimidine inhibitors of the Clk and Dyrk kinases have been developed, exploring structure-activity relationships around four different chemotypes. The most potent compounds have low-nanomolar inhibitory activity against Clk1, Clk2, Clk4, Dyrk1A and Dyrk1B. Kinome scans with 442 kinases...

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Detalhes bibliográficos
Main Authors: Coombs, Thomas C., Tanega, Cordelle, Shen, Min, Wang, Jenna L., Auld, Douglas S., Gerritz, Samuel W., Schoenen, Frank J., Thomas, Craig J., Aubé, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664191/
https://ncbi.nlm.nih.gov/pubmed/23642479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.02.096
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