The Phosphodiesterase-5 Inhibitor Vardenafil Is a Potent Inhibitor of ABCB1/P-Glycoprotein Transporter

One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an extensive screening process, we found that vardenafil, a phosphodiesterase 5 (PDE-5) inhibitor significantly reverses MDR...

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Detalhes bibliográficos
Main Authors: Ding, Pei-Rong, Tiwari, Amit K., Ohnuma, Shinobu, Lee, Jeferson W. K. K., An, Xin, Dai, Chun-Ling, Lu, Qi-Si, Singh, Satyakam, Yang, Dong-Hua, Talele, Tanaji T., Ambudkar, Suresh V., Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084276/
https://ncbi.nlm.nih.gov/pubmed/21552528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019329
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