Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

Modern methods for the identification of therapeutic leads include chemical or virtual screening of compound libraries. Nature’s library represents a vast and diverse source of leads, often exhibiting exquisite biological activities. However, the advancement of natural product leads into the clinic...

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Bibliographic Details
Main Authors: Wender, Paul A., Baryza, Jeremy L., Brenner, Stacey E., DeChristopher, Brian A., Loy, Brian A., Schrier, Adam J., Verma, Vishal A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084132/
https://ncbi.nlm.nih.gov/pubmed/21415363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015270108
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