Mice lacking phosphatase PP2A subunit PR61/B’δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

Functional diversity of protein phosphatase 2A (PP2A) enzymes mainly results from their association with distinct regulatory subunits. To analyze the functions of one such holoenzyme in vivo, we generated mice lacking PR61/B’δ (B56δ), a subunit highly expressed in neural tissues. In PR61/B’δ-null mi...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Louis, Justin V., Martens, Ellen, Borghgraef, Peter, Lambrecht, Caroline, Sents, Ward, Longin, Sari, Zwaenepoel, Karen, Pijnenborg, Robert, Landrieu, Isabelle, Lippens, Guy, Ledermann, Birgit, Götz, Jürgen, Van Leuven, Fred, Goris, Jozef, Janssens, Veerle
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084077/
https://ncbi.nlm.nih.gov/pubmed/21482799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018777108
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