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Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro
Cisplatin (cisPt), Pt(NH(3))(2)Cl(2), is a cancer drug believed to kill cells via DNA binding and damage. Recent work has implied that the cellular copper (Cu) transport machinery may be involved in cisPt cell export and drug resistance. Normally, the Cu chaperone Atox1 binds Cu(I) via two cysteines...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3084073/ https://ncbi.nlm.nih.gov/pubmed/21482801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012899108 |
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