Učitavanje...

Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

Cisplatin (cisPt), Pt(NH(3))(2)Cl(2), is a cancer drug believed to kill cells via DNA binding and damage. Recent work has implied that the cellular copper (Cu) transport machinery may be involved in cisPt cell export and drug resistance. Normally, the Cu chaperone Atox1 binds Cu(I) via two cysteines...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Palm, Maria E., Weise, Christoph F., Lundin, Christina, Wingsle, Gunnar, Nygren, Yvonne, Björn, Erik, Naredi, Peter, Wolf-Watz, Magnus, Wittung-Stafshede, Pernilla
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084073/
https://ncbi.nlm.nih.gov/pubmed/21482801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012899108
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!