Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

Cisplatin (cisPt), Pt(NH(3))(2)Cl(2), is a cancer drug believed to kill cells via DNA binding and damage. Recent work has implied that the cellular copper (Cu) transport machinery may be involved in cisPt cell export and drug resistance. Normally, the Cu chaperone Atox1 binds Cu(I) via two cysteines...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Palm, Maria E., Weise, Christoph F., Lundin, Christina, Wingsle, Gunnar, Nygren, Yvonne, Björn, Erik, Naredi, Peter, Wolf-Watz, Magnus, Wittung-Stafshede, Pernilla
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2011
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084073/
https://ncbi.nlm.nih.gov/pubmed/21482801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012899108
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