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Conserved residues modulate copper release in human copper chaperone Atox1
It is unclear how the human copper (Cu) chaperone Atox1 delivers Cu to metal-binding domains of Wilson and Menkes disease proteins in the cytoplasm. To begin to address this problem, we have characterized Cu(I) release from wild-type Atox1 and two point mutants (Met(10)Ala and Lys(60)Ala). The dynam...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516206/ https://ncbi.nlm.nih.gov/pubmed/18685091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802928105 |
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